The Spaniard will miss this weekend’s Merseyside derby against Everton and is expected to be out even longer than that.
Manager Brendan Rodgers revealed that the former Newcastle star had been carrying the knee problem for sometime and that the Reds had now taken the decision to get it fixed.
He told talkSPORT: “Jose Enrique has been struggling for a little while with an injury.
“He will probably need an operation. It’s a blow for us because he’s a very talented player.”
He added: “In fairness to him, he’s put himself out for the team to go out and play.
“But he was suffering with it and we just felt it was best for him to come out and make it right.”
Rodgers will be forced to rely on Aly Cissokho, on loan at Anfield from Valencia, as his first-choice left.
Loan signing: Aly Cissokho is suddenly significantly more important as a consequence of Enrique's injury